Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study

نویسندگان

  • Sara Pittenger Reid
  • Chia-Ning Kao
  • Lauri Pasch
  • Kanade Shinkai
  • Marcelle I. Cedars
  • Heather G. Huddleston
چکیده

BACKGROUND Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk. METHODS This is a cross-sectional study of patients seen in a multidisciplinary PCOS clinic at the University of California at San Francisco between 2006 and 2014. All participants underwent systematic evaluation with anthropometric measurements, comprehensive skin exam, transvaginal ultrasound and laboratory studies at the time of their initial visit to the clinic. Serum samples were stored and androgen studies were carried out on all stored samples at the University of Virginia. Logistic regression was employed to evaluate the association between ovarian volume or follicle number and metabolic parameters (fasting insulin, HOMA-IR, fasting glucose, 2 h glucose, waist circumference) and hyperandrogenism (free testosterone, total testosterone, DHEAS, acanthosis nigricans), controlling for age. RESULTS Three-hundred thirteen patients seen during the study period met Rotterdam criteria for PCOS and had sufficient measurements for inclusion in our analysis. The odds ratio of elevated HOMA-IR for patients with a maximum ovarian volume >10 cc was 1.9 compared to those with a maximum ovarian volume of ≤10 cc (95% CI 1.0-3.4). The odds ratio of abnormal fasting insulin for patients with higher ovarian volume was 1.8 (95% CI 1.0-3.4) compared with those with lower ovarian volume. Follicle number was not significantly associated with any metabolic parameters. CONCLUSIONS Increased ovarian volume is associated with markers of insulin resistance in PCOS. In concordance with prior studies, we did not find follicle number to be predictive of metabolic risk. Ovarian volume may serve as a useful tool to aid clinicians in their risk stratification and counseling of patients with PCOS.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association between The Number of Retrieved Mature Oocytes and Insulin Resistance or Sensitivity in Infertile Women Polycystic Ovary Syndrome

Objective The objective of this study was to evaluate LH/FSH and demographic variables on maturation stage of oocytes in patients with polycystic ovary syndrome (PCOS) with or without insulin resistance. MaterialsAndMethods Sixty patients with IVF/ICSI indication were subdivided into 3 groups as follow: 20 subjects were assigned to control (fertile women with male infertility history) group, 20...

متن کامل

Insulin resistance and adverse metabolic profile in overweight/obese and normal weight of young women with polycystic ovary syndrome

Background: Polycystic ovary syndrome (PCOs) is an endocrine-metabolic disorder. This study intends to determine the comparison of insulin resistance (IR) and metabolic disturbance in overweight/obese and normal-weight of young women with polycystic ovary syndrome. Methods: Using a comparative cross-sectional study design in 2015, 27 normal weight (18<bmi Results: 112 women with PCOS participa...

متن کامل

غلظت سرمی روی (Zn) و ارتباط آن با سطح انسولین سرم در زنان مبتلا به سندرم تخمدان پلی کیستیک

Background & objective: Polycystic ovary syndrome is the most common endocrine disorder and main cause of infertility due to anovulation in reproductive aged women.With regard to the important role of insulin resistance and hyperinsulinemia in the pathophysiology of this syndrome and the role of zinc in structure and function of insulin hormone, as zinc dishomeostasis has adverse effect on the ...

متن کامل

Metabolic and Endocrine Characteristics of Indian Women with Polycystic Ovary Syndrome

Objective Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders among women of reproductive age and the leading cause of female infertility. This study intends to evaluate the lipid profile, hormonal levels [free T3 (fT3), free T4 (fT4), thyroid stimulating hormone (TSH), insulin, luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin] in PCO...

متن کامل

Comparison of 25-hydroxyvitamin D and Calcium Levels between Polycystic Ovarian Syndrome and Normal Women

Background Given the relationship of vitamin D deficiency with insulin resistance syndrome as the component of polycystic ovary syndrome (PCOS), the main aim of this study was to compare serum level of 25- hydroxyvitamin D [25(OH)D] between PCOS patients and normal individuals. MaterialsAndMethods A cross sectional study was conducted to compare 25(OH)D level between117 normal and 125 untreated...

متن کامل

Evaluation of Fenugreek (Trigonella foenum-graceum L.), Effects Seeds Extract on Insulin Resistance in Women with Polycystic Ovarian Syndrome

PCOS (Polycystic Ovarian Syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. Fenugreek seeds extract is successfully used in lowering blood glucose. Metformin has also the same effect but in a different way. The aim of this study was the assessment of fenugreek effects on insulin resistance in women with PCOS.This was a prospective ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2017